Can Your Microbiome Be Triggering Your Migraines? A New Study Suggests "Very Likely". Summer Workshop Announcement
Alteration in microbiota in individuals with migraine and differences associated with oral prophylactics suggest careful consideration of the full spectrum of exposures is important.
We’re learning more and more about the gut-brain axis, including that microbes in our guts can produce neurotransmitters that impact our mood.
A new study investigated the differences in gut microbiota between individuals with migraine, including chronic migraine (CM) and episodic migraine (EM), and healthy control subjects.
The study involved 42 patients with episodic migraine, 45 with chronic migraine, and 53 healthy controls. The results showed no significant difference in alpha and beta diversities of microbiota between the EM, CM, and control groups.
The study examined the differences in gut microbiota between individuals with migraine, including chronic migraine (CM) and episodic migraine (EM), and healthy control subjects. Quantitative associations were found between the relative abundance of several genera and headache frequency, confirming the alteration in microbiota in individuals with migraine.
Specifically, the study found a significant association between changes in microbiota composition and clinical characteristics of migraine, such as headache frequency and severe headache intensity. It also identified altered microbiota at multiple taxonomic levels in participants with migraine compared to controls, as well as differences in microbiota composition between those with episodic and chronic migraine. These findings suggest a relationship between altered gut microbiota and migraine, which may pave the way for new treatments targeting gut microorganisms.
These findings suggest that changes in gut microbiota could play a role in the development and severity of migraine, and further research is needed to better understand this potential association.
Anxiety, Fibromyalgia (FM), and oral prophylactic medications were also found to affect the gut microbiota of participants with migraine.
A few specific taxa that showed differences in gut microbiota in individuals with migraine, anxiety, depression, and Fibromyalgia (FM). The study reported that the relative abundance of some genera of fecal microbiota (Roseburia, Eubacterium_g4, Agathobacter, PAC000195_g, and Catenibacterium) were significantly altered according to the presence of anxiety and FM, but not depression.
The fact that oral prophylactic medications were also found to affect the gut microbiota of participants with migraine means that prophylactic medications can affect the gut microbiota of individuals with migraine and should be considered when performing gut microbiota evaluation.
The authors concluded that further longitudinal studies are needed to better understand the association between prophylactic medications and gut microbiota in individuals with migraine.
At IPAK-EDU, we offer a detailed, seven-class Summer Workshop on the Microbiome. First class will be in June, Wednesdays @ 3pm ET, weather permitting :)
Citation: Yong D, Lee H, Min HG, Kim K, Oh HS, Chu MK. Altered gut microbiota in individuals with episodic and chronic migraine. Sci Rep. 2023 Jan 12;13(1):626. doi: 10.1038/s41598-023-27586-4. PMID: 36635330; PMCID: PMC9835027. https://pubmed.ncbi.nlm.nih.gov/36635330/
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