In mice, KIR+ T cells have been shown to regulate rogue T cells that cause autoimmune disease. Now we know about KIR+ T cells in humans and how important they are to immune tolerance in humans
Forgive me if I don’t understand the technical details being discussed here but it appears to me that the results show gluten may be helpful for those suffering from celiac disease. Is that correct? Isn’t that the exact opposite of what we’ve been told for years?
I don't think so, to me the article is saying that there were two groups with celiac: one intolerant to gluten, the other tolerant, and that the tolerant had more of the KIR+ T Cells, so the assumption is that they were reacting (and hence increased in abundance) to keep the active T+ Cells (that were attacking Self) under control (hence gluten was being tolerated).
One of the reasons I never took the clot shot is that I’m aware that everything about the workings of the immune system is NOT fully understood. Medical science is figuring out new aspects every day...so don’t gamble with some novel technology!
After removing the tonsils of so many children only to find out that tonsils are an important part of our immune system...I have zero trust in medical quackery.
Yes! I had my tonsils removed when I was five - it was just the medical fad at the time, the response to any normal little childhood virus. The only good thing that came out of that experience was I received a great teddybear.
Like Andy, I’m not sure about how laypeople should interpret this result as it pertains to gluten in our diets. So is gluten beneficial or not? James, please clarify.
My 17 yr old daughter was diagnosed with celiac at age 5. Can you explain it layman's terms? Both my girls are positive for celiac-associated allele(s).
My celiac daughter has a genetic risk of Moderate 1:35
HLA DQ alleles detected DQA1*05:CCBGE, 05:CCBGF
DQB1*02:CCBGG, 03:CCBGH
HLA allele intepretation based on IMGT/HLA database version 3.37.0
The patient is positive for DQ2. Celiac Disease risk from
the HLA DQA/DQB genotype is approximately 1:35 (2.9%)
DQ2 POSITIVE, two copies
DQB1*02:01/02:02 POSITIVE, one copy
My youngest Low 1:210
HLA DQ alleles detected DQA1*01:CCBEP, 02:DWH
DQB1*02:CCBDS, 06:CCFGY
HLA allele intepretation based on IMGT/HLA database version 3.37.0
The patient is positive for DQB1*02, one half of the DQ2
heterodimer. The Celiac Disease risk from the HLA DQA/DQB
genotype is approximately 1:210 (0.5%). This is less than
Love the comic representations of cells.
Forgive me if I don’t understand the technical details being discussed here but it appears to me that the results show gluten may be helpful for those suffering from celiac disease. Is that correct? Isn’t that the exact opposite of what we’ve been told for years?
Thanks, Andy!
I don't think so, to me the article is saying that there were two groups with celiac: one intolerant to gluten, the other tolerant, and that the tolerant had more of the KIR+ T Cells, so the assumption is that they were reacting (and hence increased in abundance) to keep the active T+ Cells (that were attacking Self) under control (hence gluten was being tolerated).
But I could be wrong.
Thanks, Bob!
Cool. Glad you called out the troll too.
One of the reasons I never took the clot shot is that I’m aware that everything about the workings of the immune system is NOT fully understood. Medical science is figuring out new aspects every day...so don’t gamble with some novel technology!
Yes! The current understanding is very simplistic. The standard blood panel is laughable.
After removing the tonsils of so many children only to find out that tonsils are an important part of our immune system...I have zero trust in medical quackery.
Yes! I had my tonsils removed when I was five - it was just the medical fad at the time, the response to any normal little childhood virus. The only good thing that came out of that experience was I received a great teddybear.
Like Andy, I’m not sure about how laypeople should interpret this result as it pertains to gluten in our diets. So is gluten beneficial or not? James, please clarify.
JLW - P53 activation and immune dysregulation at work.
My 17 yr old daughter was diagnosed with celiac at age 5. Can you explain it layman's terms? Both my girls are positive for celiac-associated allele(s).
My celiac daughter has a genetic risk of Moderate 1:35
HLA DQ alleles detected DQA1*05:CCBGE, 05:CCBGF
DQB1*02:CCBGG, 03:CCBGH
HLA allele intepretation based on IMGT/HLA database version 3.37.0
The patient is positive for DQ2. Celiac Disease risk from
the HLA DQA/DQB genotype is approximately 1:35 (2.9%)
DQ2 POSITIVE, two copies
DQB1*02:01/02:02 POSITIVE, one copy
My youngest Low 1:210
HLA DQ alleles detected DQA1*01:CCBEP, 02:DWH
DQB1*02:CCBDS, 06:CCFGY
HLA allele intepretation based on IMGT/HLA database version 3.37.0
The patient is positive for DQB1*02, one half of the DQ2
heterodimer. The Celiac Disease risk from the HLA DQA/DQB
genotype is approximately 1:210 (0.5%). This is less than
the 1% risk in the general population.
DQA1*05:01/05:05 NEGATIVE
DQB1*02:01/02:02 POSITIVE, one copy
So now the I would like to build more KIR+CD8+ T cells and how is that possible? Diet, medicine,
exercise, stem cells?
So now the I would like to build more KIR+CD8+ T cells and how is that possible? Diet, medicine,
exercise, stem cells?
🚨🚨🚨 please be aware https://open.substack.com/pub/sagehana/p/dear-substack-readers-and-writers?r=ykqw5&utm_medium=ios&utm_campaign=post