Evidence published in April 2021 shows that the chance for vaccine immunity was lost with the Beta variant. Plus some bad and good news about Delta and Omicron from realm of viral evolutionaryomics.
Omicron might yet prove the `vaccine` that (nearly) none of us can avoid, but one which helps provoke a healthy immune response and does so with far less risk than the Pfizer or Moderna mRNA vaccines. Time will shortly tell.
Regarding the"inevitable" infection: the US is at a cumulated 16% of the total population infected, after two years. Many countries are way below that. Canada: 5%, Germany: 8%.
With individual susceptibility towards infection not factored in, contributing factors largely unknown, and questionable efficacy of lockdowns, it might be a decade before some people catch it, if ever.
These are based only on confirmed cases. Estimates are much more than this 51mn. Around 100 million Americans by end of 2020 alone or 31% of the US. We're probably looking at 50% if not more by now.
To be fair, underreporting can be safely assumed. But the article you linked is merely based on modeling, no real-world data as far as I can tell.
On the other hand there was infection-only seroprevalence of ~20% in early summer of 2021, with a reported 2:1 ratio. (for the US)
This is roughly supported by the recent data from Austria and Germany:
Austria, while PCR carpet-bombing the population with more than 10x the daily tests per capita vs. Germany since this fall, only has an incidence roughly 2x. Looks like saturation.
So if we assume a 1:2 underreporting factor, my point still stands. Omicron could speed this up, but from a public health perspective it's still bonkers.
If the RT-qPCR is incorrectly pairing cases to actual disease infections beyond the linear response of the PCR output (90% potential surplus cases over actual infections), could this number be marginally lower or even substantially lower in reality?
Thank you. But we are playing with numbers a bit. It is 52 million confirmed cases in the USA. But number infected always exceeds the confirmed cases. The Center for Disease Control reports an estimated 146.6 million infections -- roughly 1/3 of the US population. Please see link: https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/burden.html
What if bioweapon defense research focused on loss of lethality and gain of infectiousness instead of gain-of-function? Would this kill off a great deal of the vaccine industry profits? We didn't have the kind of ability that we have now to create artificial viral strains in the lab in the 1950s and 1960s when the injectable vaccine became the one and only acceptable solution to epidemics. Should we rethink that? No way to monetize a self-spreading naturally inoculating virus like omicron, though. What we need to do is to end the issuing of all medical patents. That's what I think. If you work in the theoretical sciences, you don't understand why the applied science crowd can only be motivated by huge financial incentives to do good work.
Q - will prophylaxis like quercetin to get zinc into cells, D, C and others help? and I value your work and would appreciate it if in your next major, detailed article you include language explaining to people without advanced degrees in biology. I am inclined to take your course.
Quercetin (and EGCG) get zinc into cells system wide. IVM & HCQ focus on getting zinc into the lung cells more. For a respiratory viral disease that is a huge plus. I don't see any reason why any of those would not work against the moronic variant. Just my SWAG.
Thanks so much for responding. I was not familiar with EGCG. Good to know and integrate this body of knowledge with conventional. Hypothetical Q - if someone wanted to get moronic to acquire natural immunity, would getting zinc into the cells prevent that? Also here is a piece I wrote about IVM - my first Substack after being censored on Medium. https://coronawise.substack.com/p/open-letter-and-challenge-for-rachel
I'm not sure at what point your body counter attacks the virus. If it does it before it gets into the cell then yes. Zinc prevents the virus from replilcating once it is in the cell. EGCG is green tea extract. Dr Zelenko says quercetin works better but if you can't get it you can use EGCG. I have both in my multi-vitamin.
I wouldn't recommend any "moronic parties" although it sounds fun. Given the rate of spread we'll all get it before the end of season in April. Be prepared and hit it early with the shotgun approach.
"I'm not sure at what point your body counter attacks the virus".
When the body releases excessive antibodies in trying to kill some intruders.
Dr Bakdti (sic) expressly warns about the dangers of a second shot because it could trigger that storm.
From what I read, yes, Quercetin > EGCG. They all said take the ionophores in combo with Zinc, and perhaps Doxycycline. Never did they say take Quercetin from some multi-vitamins.
One of the theories trying to explain the origins of SARS-COV-2 is from Dan Sirotkin (harvard2thebighouse.substack.com). He claims that the earliest circulating strains might have come from de-attenuation of a LAV vaccine that was tested on unwitting subjects in Wuhan. A process of de-attenuating might result from common evolutionary pressures causing the re-emergence of previously effective solutions. So if we see this ADE enhancing epitope rapidly emerging as early as Jan 2020 that might fit such a theory. Dan Sirotkin also suggested that the apparent early high fatality rate in Wuhan might have been caused by ADE. The population might been exposed to a vaccine candidate and then a mutated version of that virus, with ADE enhancing epitopes exactly as discussed here.
If there really is a Pfizer vs Moderna modified spike protein difference that involves that exact sequence, I would be very interested to hear why. Amidst such unlikely miracles as producing vaccine candidates in 48 hours for a novel virus, some of these drug company wizards were also tweaking out suspect sequences that they identified how?
I took the Pfizer nucleic acid sequence (Fig. 1) from the Stanford sequence citation above, and ran it through the ExPASy translation tool. I actually do see LYQDVNC in the Pfizer sequence (as well as the Moderna sequence (Fig. 2)) What am I missing or doing wrong?
Shocking if true that Moderna and Pfizer have differing spike antigen sequences. But Moderna and Pfizer seem to have identical spike proteins that get produced by their mRNAs. So no tinkering with spike antigen at Moderna, or do you have additional sources of moderna mRNA sequence ?
I ran an alignment comparing the Moderna and Pfizer sequences from the Stanford source cited above, using SIM from ExPASy, and the two spike protein sequences look identical to me too. That source is interesting because it seems they actually sequenced the RNA left over from vaccine vials, do I understand this correctly? I do see the two prolines (PP) the companies engineered in. Did not compare to wild-type Wuhan.
With your just released updated correction that both Moderna and Pfizer contain the ADE epitope LYQDVNC, is it a moot point now that since much of the world took these already ... is a correction now going to change/attenuate their future potential outcome? Also, since the pathologist found that all four popular vaccines showed the ADE tissue response, is this epitope LYQDVNC also in the other two?
Omicron might yet prove the `vaccine` that (nearly) none of us can avoid, but one which helps provoke a healthy immune response and does so with far less risk than the Pfizer or Moderna mRNA vaccines. Time will shortly tell.
Regarding the"inevitable" infection: the US is at a cumulated 16% of the total population infected, after two years. Many countries are way below that. Canada: 5%, Germany: 8%.
With individual susceptibility towards infection not factored in, contributing factors largely unknown, and questionable efficacy of lockdowns, it might be a decade before some people catch it, if ever.
Where do you get the 16% number? I keep hearing well north of 100,000,000, i.e. 1/3 or more.
https://ourworldindata.org/covid-cases#cumulative-confirmed-cases-per-million-people
These are based only on confirmed cases. Estimates are much more than this 51mn. Around 100 million Americans by end of 2020 alone or 31% of the US. We're probably looking at 50% if not more by now.
https://www.eurekalert.org/news-releases/926424
I'm not quite convinced.
To be fair, underreporting can be safely assumed. But the article you linked is merely based on modeling, no real-world data as far as I can tell.
On the other hand there was infection-only seroprevalence of ~20% in early summer of 2021, with a reported 2:1 ratio. (for the US)
This is roughly supported by the recent data from Austria and Germany:
Austria, while PCR carpet-bombing the population with more than 10x the daily tests per capita vs. Germany since this fall, only has an incidence roughly 2x. Looks like saturation.
So if we assume a 1:2 underreporting factor, my point still stands. Omicron could speed this up, but from a public health perspective it's still bonkers.
Desperate times....
For deeper dive, here's the study published in Nature. Wild times indeed. Take your Vitamin D 😁
https://www.nature.com/articles/s41586-021-03914-4
Thanks. CDC now says 146.6 million USA cases. https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/burden.html
If the RT-qPCR is incorrectly pairing cases to actual disease infections beyond the linear response of the PCR output (90% potential surplus cases over actual infections), could this number be marginally lower or even substantially lower in reality?
Thank you. But we are playing with numbers a bit. It is 52 million confirmed cases in the USA. But number infected always exceeds the confirmed cases. The Center for Disease Control reports an estimated 146.6 million infections -- roughly 1/3 of the US population. Please see link: https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/burden.html
What if bioweapon defense research focused on loss of lethality and gain of infectiousness instead of gain-of-function? Would this kill off a great deal of the vaccine industry profits? We didn't have the kind of ability that we have now to create artificial viral strains in the lab in the 1950s and 1960s when the injectable vaccine became the one and only acceptable solution to epidemics. Should we rethink that? No way to monetize a self-spreading naturally inoculating virus like omicron, though. What we need to do is to end the issuing of all medical patents. That's what I think. If you work in the theoretical sciences, you don't understand why the applied science crowd can only be motivated by huge financial incentives to do good work.
Read these articles from Dan Sirotkin first :-)
https://harvard2thebighouse.substack.com/p/understanding-covid-19-and-seasonal
and
https://harvard2thebighouse.substack.com/p/a-grin-without-a-cat
Q - will prophylaxis like quercetin to get zinc into cells, D, C and others help? and I value your work and would appreciate it if in your next major, detailed article you include language explaining to people without advanced degrees in biology. I am inclined to take your course.
Quercetin (and EGCG) get zinc into cells system wide. IVM & HCQ focus on getting zinc into the lung cells more. For a respiratory viral disease that is a huge plus. I don't see any reason why any of those would not work against the moronic variant. Just my SWAG.
Thanks so much for responding. I was not familiar with EGCG. Good to know and integrate this body of knowledge with conventional. Hypothetical Q - if someone wanted to get moronic to acquire natural immunity, would getting zinc into the cells prevent that? Also here is a piece I wrote about IVM - my first Substack after being censored on Medium. https://coronawise.substack.com/p/open-letter-and-challenge-for-rachel
I agree with TRM's reply to you. Dr Perlwoman.
LOL, decades ago I was called Perlperson. Perlwoman works too.
I'm not sure at what point your body counter attacks the virus. If it does it before it gets into the cell then yes. Zinc prevents the virus from replilcating once it is in the cell. EGCG is green tea extract. Dr Zelenko says quercetin works better but if you can't get it you can use EGCG. I have both in my multi-vitamin.
I wouldn't recommend any "moronic parties" although it sounds fun. Given the rate of spread we'll all get it before the end of season in April. Be prepared and hit it early with the shotgun approach.
"I'm not sure at what point your body counter attacks the virus".
When the body releases excessive antibodies in trying to kill some intruders.
Dr Bakdti (sic) expressly warns about the dangers of a second shot because it could trigger that storm.
From what I read, yes, Quercetin > EGCG. They all said take the ionophores in combo with Zinc, and perhaps Doxycycline. Never did they say take Quercetin from some multi-vitamins.
I agree: don't go seek it. If and when it comes, then kick its lab-ass!
NAC also helps.
Surprisingly, beware that NOT all labels of Vitamind D3 are the same. Ask around.
There are quite a few papers on NAC over at
https://c19early.com/treatments.html#n-acetylcysteine
I have found that NAPROXEN can be taken as both preventative and treatment.
I got some of that as well but there is only 1 study on it so far.
https://c19early.com/treatments.html#naproxen
One of the theories trying to explain the origins of SARS-COV-2 is from Dan Sirotkin (harvard2thebighouse.substack.com). He claims that the earliest circulating strains might have come from de-attenuation of a LAV vaccine that was tested on unwitting subjects in Wuhan. A process of de-attenuating might result from common evolutionary pressures causing the re-emergence of previously effective solutions. So if we see this ADE enhancing epitope rapidly emerging as early as Jan 2020 that might fit such a theory. Dan Sirotkin also suggested that the apparent early high fatality rate in Wuhan might have been caused by ADE. The population might been exposed to a vaccine candidate and then a mutated version of that virus, with ADE enhancing epitopes exactly as discussed here.
If there really is a Pfizer vs Moderna modified spike protein difference that involves that exact sequence, I would be very interested to hear why. Amidst such unlikely miracles as producing vaccine candidates in 48 hours for a novel virus, some of these drug company wizards were also tweaking out suspect sequences that they identified how?
That was a dynamite post. Thanks.
IF they allow it.
They are priming people for the third dose in Australia now.
I took the Pfizer nucleic acid sequence (Fig. 1) from the Stanford sequence citation above, and ran it through the ExPASy translation tool. I actually do see LYQDVNC in the Pfizer sequence (as well as the Moderna sequence (Fig. 2)) What am I missing or doing wrong?
Hmmm... It may be my focus on one open reading frame. Will double check and report back. Thank you.
Shocking if true that Moderna and Pfizer have differing spike antigen sequences. But Moderna and Pfizer seem to have identical spike proteins that get produced by their mRNAs. So no tinkering with spike antigen at Moderna, or do you have additional sources of moderna mRNA sequence ?
https://twitter.com/gibarian1979/status/1475385967158693891
I will post the alignment of the translation I got back.
I ran an alignment comparing the Moderna and Pfizer sequences from the Stanford source cited above, using SIM from ExPASy, and the two spike protein sequences look identical to me too. That source is interesting because it seems they actually sequenced the RNA left over from vaccine vials, do I understand this correctly? I do see the two prolines (PP) the companies engineered in. Did not compare to wild-type Wuhan.
Stanford manuscript, text with figures
RNA-1273/blob/main/Assemblies%20of%20putative%20SARS-CoV2-spike-encoding%20mRNA%20sequences%20for%20vaccines%20BNT-162b2%20and%20mRNA-1273.docx.pdf
Another rabbit hole that's probably not worth everyone's time. But it is WEIRD to see a full-length protein encoded by the anti-sense of Pfizer's spike mRNA and not Moderna's. https://popularrationalism.substack.com/p/both-moderna-and-pfizer-spike-protein
#StrangeThingsIFound #Bioinformatics #LearnFromMistakes #mRNABiologics
Another rabbit hole that's probably not worth everyone's time. But it is WEIRD to see a full-length protein encoded by the anti-sense of Pfizer's spike mRNA and not Moderna's. https://popularrationalism.substack.com/p/both-moderna-and-pfizer-spike-protein
#StrangeThingsIFound #Bioinformatics #LearnFromMistakes #mRNABiologics
>unknown_aa_sequence_from_pfizer_3'-5'-direction
MQYQLESSCVVQFHALQHGLRIVLVELAAAATATTALQAATAAGHATQHDCDHHDGNQSGDKAQPDVPGPLDVLLVLPQFLQVDQALVQILGHLVQPVDLFLDVHDAGIDSADIAQVHVGACVVLKVLVQFLFEAVQLGLQRVVHGIVHNADHDVAVARHEGVVGGDDLGLVEVPLCHEPMGAVGHEHAFSRKVGFAVVADGWSGGEILLLSGHICHVQKHHAVRGRLREAHQVVALAAKVHSLALAQHTLRHLGGGQIGRGSNLGGSDQLLGHVCLEALQSACDQSVDLHLGLRRVQSAQDIVQHRADGAEVGGQLLDQGVQCLGILVDHVLQLSQGACCAAQAVLDLADGAVELVGDQLLVLVQHILGHSDAVEPVGHLHSKGDLQSGACSKCPAACDCAGQQGRCVLGDHLIGQQRRQHCQSVKLLGANQIPGGNVAQTIAILLDEAGVGQCHFVEQQVLDEAPLAGLARIGQNLAEIEAAEVLDRRGLVDLLHLGEHLLGVLVLFHGDPCQGSIQLGAEAAVLQQQVGALGGIAADVHGAVHAGLGHGHRQDLCGHADGEVGGDSDRVVGVGHAVLGAQRHCVGNDALAGHASGSPRAVCLCLVAGADSSADGDVALVAIVHVLGSDQTAGSGLKHIAAGGVHPPCRCQLIGVNGHGHFGTVHVLVQHCHLIAGVGARGDHRHSAEAARGDVQDFQCLGISNGVCGIGDIPAKLLEWQELLVALCQHAGAGQAVEVEVHAFVLHEIGAFLRAAHCGRGMQQFEAQHHHSVGLIAHAICGLKAVGLQWEVAVEAFHAVTRGAAGLIDLGGDVPLEGLQIGLPEQPVQVIVVAADFGVQVVAVPGNHTAGEVVGQLVVVVGDLACLSRGNLPHFISPDHEAVGVHVCEAQVVQLGRGHAVALEGAEAGGVVQHGVVGHAIADPLPVPGVHRGESGGIEHLAEGAQIGDIGEPHDGFGGLHPEVAGLVDALFHGEGLQGALCLAQRIQSTIHGVGDGAVLVVLQQEGSRLQVAHIVSGGTSCPSAAAIARCQVASVQGQQCLKPGDVDADGQIHQGFQSREALRQIPHEVDRGVLAVDLEVAVDVLKHELAQVLEVALLAFQVHQERLGHVLEGAVVGAAVHPELAFHPALVVLVVVDAQEGVVAELELAHFDDHVGGVVHDQQALGLAVQCGAEDPASDDVGLLGAGKVHPVVEGQHGVVESLGAIGAGHVDGVEPGHVAEERQEQVLGRVQHAGSEHLVGVVHASGKAVGVGWRQLCSGGQVHTLAGHQRQQHQEHEHGGGFSLSLWGPEEY
I was under the impression that the mRNA sequences had to be a wee bit
different for proprietary reasons.
With your just released updated correction that both Moderna and Pfizer contain the ADE epitope LYQDVNC, is it a moot point now that since much of the world took these already ... is a correction now going to change/attenuate their future potential outcome? Also, since the pathologist found that all four popular vaccines showed the ADE tissue response, is this epitope LYQDVNC also in the other two?
I plan on avoiding the jab forever. I'm going to meet my maker a pureblood as he made me. ☺️