The other major (an very relevant) aspect that is overlooked is the targeting technology built into the LNP: "We developed CD117/LNP–messenger RNA (mRNA), a lipid nanoparticle (LNP) that encapsulates mRNA and is targeted to the stem cell factor receptor (CD117) on HSCs. " The research group used LNPs that had antibodies that bind to CD117 (c-Kit).
"CD117 is internalized after the binding of SCF (stem cell factor), which we hypothesize may facilitate or augment LNP internalization" - "By decorating the surface of LNPs with targeting moieties, we have demonstrated effective targeting to specific cell types, such as endothelial cells and T cells, with therapeutic efficacy upon single intravenous injection in mice, as described in our previous reports (9–11)." - "Humanized" antibodies carry a great deal of immunologic risk.
The language of "effective targeting" omits an important component to "safe and effective" gene editing for non-heritable stem cells": specificity of target. In the text they admit that there is off-target internalization of the LNPs: "Intravenous administration of CD117/LNP-Luc generated luciferase activity in the femur at 24 hours, whereas IgG/LNP-Luc did not (Fig. 3A). Both control IgG/LNP-Luc and CD117/LNP-Luc showed comparable luciferase activity in the liver because LNPs bind apolipoprotein E (ApoE) and are non-specifically targeted to the low-density lipo-protein (LDL) receptor, which is expressed on hepatocytes (8)." There was also the observation that lung cells were affected by the LNPs.
This is technology applied in mice and the level of work done by this group is heads-and-shoulders better than the data FDA received from either Pfizer, Moderna or whatever R&D group supplied the "safety" data to the FDA for the COVID jabs.
"2. Immunological implications: The immune system's response to the in vivo gene editing process isn't entirely clear, and there could be unforeseen consequences related to immune reactions."
Gene therapy will fail. The gene-edited, corrected protein/epitopes will be perceived as cancer neoantigens and will be destroyed.
I think much treatment could be prevented by taking a step back, and living more in sync with nature, like we originally did. Both spending more actual time in nature, but also eating more naturally -- i.e. eat less processed food, and try to eat foods as close to the source and unprocessed as possible. You need to educate yourself, for example about seed oils, and other highly processed oils. Also, preventative treatments, such as injecting mixtures into babies and children should be investigated thoroughly for side effects in double blind studies, using true placebos containing only salt water.
An ounce of prevention (mainly by educating yourself) is worth a pound of cure.
Seems like the Pro Stem Cells Reprogramming argument might be summarized as: the conventional approach is very imperfect.
The other major (an very relevant) aspect that is overlooked is the targeting technology built into the LNP: "We developed CD117/LNP–messenger RNA (mRNA), a lipid nanoparticle (LNP) that encapsulates mRNA and is targeted to the stem cell factor receptor (CD117) on HSCs. " The research group used LNPs that had antibodies that bind to CD117 (c-Kit).
"CD117 is internalized after the binding of SCF (stem cell factor), which we hypothesize may facilitate or augment LNP internalization" - "By decorating the surface of LNPs with targeting moieties, we have demonstrated effective targeting to specific cell types, such as endothelial cells and T cells, with therapeutic efficacy upon single intravenous injection in mice, as described in our previous reports (9–11)." - "Humanized" antibodies carry a great deal of immunologic risk.
The language of "effective targeting" omits an important component to "safe and effective" gene editing for non-heritable stem cells": specificity of target. In the text they admit that there is off-target internalization of the LNPs: "Intravenous administration of CD117/LNP-Luc generated luciferase activity in the femur at 24 hours, whereas IgG/LNP-Luc did not (Fig. 3A). Both control IgG/LNP-Luc and CD117/LNP-Luc showed comparable luciferase activity in the liver because LNPs bind apolipoprotein E (ApoE) and are non-specifically targeted to the low-density lipo-protein (LDL) receptor, which is expressed on hepatocytes (8)." There was also the observation that lung cells were affected by the LNPs.
This is technology applied in mice and the level of work done by this group is heads-and-shoulders better than the data FDA received from either Pfizer, Moderna or whatever R&D group supplied the "safety" data to the FDA for the COVID jabs.
Yep, great detail to pull out!
"2. Immunological implications: The immune system's response to the in vivo gene editing process isn't entirely clear, and there could be unforeseen consequences related to immune reactions."
Gene therapy will fail. The gene-edited, corrected protein/epitopes will be perceived as cancer neoantigens and will be destroyed.
https://vinuarumugham.substack.com/p/the-role-of-vaccine-induced-autoimmunity
I think much treatment could be prevented by taking a step back, and living more in sync with nature, like we originally did. Both spending more actual time in nature, but also eating more naturally -- i.e. eat less processed food, and try to eat foods as close to the source and unprocessed as possible. You need to educate yourself, for example about seed oils, and other highly processed oils. Also, preventative treatments, such as injecting mixtures into babies and children should be investigated thoroughly for side effects in double blind studies, using true placebos containing only salt water.
An ounce of prevention (mainly by educating yourself) is worth a pound of cure.