Alarmism and sensationalism are alive and well as a person with comorbidities survives intubation and three plasma exchanges. The case study, the Editorial and Medpage Today suffer serious problems.
And, we must always ask: Has she received the mRNA jabs? Almost certainly YES for Canada. With the Igg4 class switching, she was in a dangerous position to start with, as, I fear, are most jabbed folks.
Thanks to Dr. Weiler for clear analytical critique which helps to arm us against the increasing prevalence of "misplaced alarmism" (crafted medical terrorism) .
As a virologist I would love to tell these people: It's not the virus stupid! My own work with influenza has shown that the severe lung disease is a result of neutrophilic infiltrates and elevated levels of IL6. Treatment with anti-IL6 antibodies abrogates the lung inflammation. That being said, just as with SARS infection, by the time the patient gets to the hospital the virus is no longer present so treating with antiviral is a misuse of resources which leads to what you stated as iatrogenic harms. I also agree with the hyperbaric oxygen treatment. I said the same in 2020 that ventilation was the WRONG way to go as it most likely causes more damage due to the shear forces of the air pressure and the secondary infections. But I'm not a clinician so what do I know? I also know that amantadine/rimantadine became useless long ago as most flu viruses have gained resistance to those drugs. Tamiflu needs to be given within 72 hours of infection to be useful in any way and with H5N1 the dose would have to be much higher than with seasonal flu viruses. I know, I did the studies in animal models. So, unfortunately, we will most likely see a repeat of the hospital killing patients who have been diagnosed with avian flu infection.
"Ferrets were protected from lethal infection with the A/Vietnam/1203/04 (H5N1) virus by oseltamivir (5 mg/kg of body weight/day) given 4 h after virus inoculation, but higher daily doses (25 mg/kg) were required for treatment when it was initiated 24 h after virus inoculation." https://pmc.ncbi.nlm.nih.gov/articles/PMC1855473/
Not likely someone will known within 4 hours of getting infected with H5N1 virus. But wait , there's more....."Importantly, all ferrets that survived the initial infection were rechallenged with homologous virus after 21 days and were completely protected from infection."
Actively acquired immunity protects from reinfection.
I keep thinking how different everything would be if doctors would use intravenous ascorbate drug and ozone to treat patients with severe viral infections in hospital.
Do you know any hospital that would allow such a thing? I have seen 50 grams given IV over 4 hr give excellent symptomatic relief for impending/ asthma’s attack on more than one occasion!
No hospital within the publicly funded health system here in Canada would permit it. Many years ago we could simply make an appointment to get an IV C treatment at a doctor's clinic in Toronto and pay the doctor for it (about $130 per session) but now medical doctors aren't allowed, and naturopaths can't do it without an expensive assessment that costs about a grand.
It’s too bad that most physicians are “trained” as they say, rather than combining a liberal arts/ humanities undergraduate degrees to help them with critical thinking and analyzation and perhaps a healthy cynicism to boot!
I'm not sure you have it right, Dr. Lyons-Weiler. According to virologist Henry Niman - https://x.com/HNimanFC - who has been studying H5N1 sequences for over 20 years the E190D mutation (the E186D mutation in H3 numbering) is the only mutation which is present in sequences from all of the last four flu pandemics - 1918, 1957, 1968 and 2009 - and it has only been found in two H5N1 sequences, which are from the British Columbia teen and the Louisiana man, both of whom got severely ill.
So I think there is reason to at least suspect the virus is gradually adapting to humans as it has adapted to cats and elephant seals, among other species, for which it is very deadly, and that people should be made aware there is a significant possibility we will soon have a deadly pandemic which they should be preparing for now in case it happens, e.g., by taking supplements like D3/K2 and procuring medications such as are being sold by The Wellness Company (to be taken under telemedicine supervision, ideally, in the event of sickness) so people can hopefully avoid severe disease and needing to go to a hospital.
So I think some fear mongering, if you want to call it that, may be justified to wake people up to what may be a likely disaster coming - as long as it isn't used to justify the promoting of improperly tested vaccines or treatments and/or government mandates which violate what should be inalienable rights.
I would love to see a roundtable discussion on this issue, including yourself, Dr. Vanden Bossche, Dr. Bridle, Dr. Malone, Dr. McCullough and vaccine developer Nikolai Petrovsky who is working on an H5N1 vaccine. I think a lot of other people would, too.
As a virologist who worked many years with H5N1 and also worked on the first H5N1 vaccine that was stockpiled for human use, I can tell you that this has to do with host range restriction due to the receptor that influenza viruses use. Human influenza viruses use a2,6 linked sialic acids to invade cells while avian viruses use a2,3 sialic acid residues. Genetic mutations only play a role if they alter the receptor binding capacity of the virus. The reason some people get more ill when infected with avian viruses has to do with where the virus locates to as the a2,3 sialic acids can be found deep in the lungs. These sialic acids are also found in the eye so that's another reason most people get conjunctivitis as well. Look at receptor distribution in animals and you will see that's why cats are getting infected with avian viruses although for them it is more of a GI infection as we see in birds.
And, we must always ask: Has she received the mRNA jabs? Almost certainly YES for Canada. With the Igg4 class switching, she was in a dangerous position to start with, as, I fear, are most jabbed folks.
Thanks to Dr. Weiler for clear analytical critique which helps to arm us against the increasing prevalence of "misplaced alarmism" (crafted medical terrorism) .
As a virologist I would love to tell these people: It's not the virus stupid! My own work with influenza has shown that the severe lung disease is a result of neutrophilic infiltrates and elevated levels of IL6. Treatment with anti-IL6 antibodies abrogates the lung inflammation. That being said, just as with SARS infection, by the time the patient gets to the hospital the virus is no longer present so treating with antiviral is a misuse of resources which leads to what you stated as iatrogenic harms. I also agree with the hyperbaric oxygen treatment. I said the same in 2020 that ventilation was the WRONG way to go as it most likely causes more damage due to the shear forces of the air pressure and the secondary infections. But I'm not a clinician so what do I know? I also know that amantadine/rimantadine became useless long ago as most flu viruses have gained resistance to those drugs. Tamiflu needs to be given within 72 hours of infection to be useful in any way and with H5N1 the dose would have to be much higher than with seasonal flu viruses. I know, I did the studies in animal models. So, unfortunately, we will most likely see a repeat of the hospital killing patients who have been diagnosed with avian flu infection.
"Ferrets were protected from lethal infection with the A/Vietnam/1203/04 (H5N1) virus by oseltamivir (5 mg/kg of body weight/day) given 4 h after virus inoculation, but higher daily doses (25 mg/kg) were required for treatment when it was initiated 24 h after virus inoculation." https://pmc.ncbi.nlm.nih.gov/articles/PMC1855473/
Not likely someone will known within 4 hours of getting infected with H5N1 virus. But wait , there's more....."Importantly, all ferrets that survived the initial infection were rechallenged with homologous virus after 21 days and were completely protected from infection."
Actively acquired immunity protects from reinfection.
I keep thinking how different everything would be if doctors would use intravenous ascorbate drug and ozone to treat patients with severe viral infections in hospital.
Do you know any hospital that would allow such a thing? I have seen 50 grams given IV over 4 hr give excellent symptomatic relief for impending/ asthma’s attack on more than one occasion!
No hospital within the publicly funded health system here in Canada would permit it. Many years ago we could simply make an appointment to get an IV C treatment at a doctor's clinic in Toronto and pay the doctor for it (about $130 per session) but now medical doctors aren't allowed, and naturopaths can't do it without an expensive assessment that costs about a grand.
The dosing is interesting; the most I have read about was 13 grams over 7 hrs (for sepsis, I believe).
😂
It needs to be diluted in a liter to prevent damage to vein wall(scalding) from heavy concentrations
How is ozone used?
It’s too bad that most physicians are “trained” as they say, rather than combining a liberal arts/ humanities undergraduate degrees to help them with critical thinking and analyzation and perhaps a healthy cynicism to boot!
There ‘s more that one way to skin a cat!
Thanks for this. I, being a conspiracy theorist and not a Doctor..... was looking for the diagnosis.
Where is that process? How do they/did they know if was this? Was there a PCR test or something?
I'm not sure you have it right, Dr. Lyons-Weiler. According to virologist Henry Niman - https://x.com/HNimanFC - who has been studying H5N1 sequences for over 20 years the E190D mutation (the E186D mutation in H3 numbering) is the only mutation which is present in sequences from all of the last four flu pandemics - 1918, 1957, 1968 and 2009 - and it has only been found in two H5N1 sequences, which are from the British Columbia teen and the Louisiana man, both of whom got severely ill.
So I think there is reason to at least suspect the virus is gradually adapting to humans as it has adapted to cats and elephant seals, among other species, for which it is very deadly, and that people should be made aware there is a significant possibility we will soon have a deadly pandemic which they should be preparing for now in case it happens, e.g., by taking supplements like D3/K2 and procuring medications such as are being sold by The Wellness Company (to be taken under telemedicine supervision, ideally, in the event of sickness) so people can hopefully avoid severe disease and needing to go to a hospital.
So I think some fear mongering, if you want to call it that, may be justified to wake people up to what may be a likely disaster coming - as long as it isn't used to justify the promoting of improperly tested vaccines or treatments and/or government mandates which violate what should be inalienable rights.
I would love to see a roundtable discussion on this issue, including yourself, Dr. Vanden Bossche, Dr. Bridle, Dr. Malone, Dr. McCullough and vaccine developer Nikolai Petrovsky who is working on an H5N1 vaccine. I think a lot of other people would, too.
As a virologist who worked many years with H5N1 and also worked on the first H5N1 vaccine that was stockpiled for human use, I can tell you that this has to do with host range restriction due to the receptor that influenza viruses use. Human influenza viruses use a2,6 linked sialic acids to invade cells while avian viruses use a2,3 sialic acid residues. Genetic mutations only play a role if they alter the receptor binding capacity of the virus. The reason some people get more ill when infected with avian viruses has to do with where the virus locates to as the a2,3 sialic acids can be found deep in the lungs. These sialic acids are also found in the eye so that's another reason most people get conjunctivitis as well. Look at receptor distribution in animals and you will see that's why cats are getting infected with avian viruses although for them it is more of a GI infection as we see in birds.