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Pathogenic Priming, My Predicted Nightmare
Occasionally I'm sent papers by colleagues who congratulate me on citations. Anyone who knows me knows that I wish my April 2020 predictions were all wrong.
Case Report: Subacute thyroiditis after receiving inactivated SARS-CoV-2 vaccine (BBIBP-CorV) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355607/
Pi L, Lin J, Zheng Y, Wang Z, Zhou Z. Case Report: Subacute thyroiditis after receiving inactivated SARS-CoV-2 vaccine (BBIBP-CorV). Front Med (Lausanne). 2022 Jul 22;9:918721. doi: 10.3389/fmed.2022.918721. PMID: 35935798; PMCID: PMC9355607.
“As there are many proteins originated from or similar to the pathogen virus in the inactivated virus vaccines, molecular mimicry seems to play a potential role in the development of inactivated SARS-CoV-2-vaccine-related subacute thyroiditis. Spike (S) protein is an immunodominant antigen of SARS-CoV-2, which is also the target of neutralizing antibodies (8, 15, 17). A previous study has proven that there is similarity between S protein and various self-tissue proteins in human (18). It has also been shown that thyroid peroxidase (TPO) sequences share homology and similarity with sequences in S protein, which to extent supported another finding that human monoclonal antibodies against SARS-CoV-2 S protein react with TPO (19). Furthermore, by comparing immunogenic epitopes of SARS-CoV-2 with human proteins, Lyons-Weiler found a high degree of homology with various tissues including thyroid gland (20). In addition, a pilot study further implied that proinflammatory cytokines could increase the expression of angiotensin-converting-enzyme-2 (ACE-2), the receptor for cellular entry of SARS-CoV-2, which might facilitate the entering of SARS-CoV-2 into thyroid and contribute to the understanding of pathogenesis in subacute thyroiditis after SARS-CoV-2 infection or vaccination (21).”
“Inactivated SARS-CoV-2 vaccine may be a causal trigger leading to subacute thyroiditis. Clinicians should be aware of subacute thyroiditis as a possible thyroid-related side effect of an inactivated SARS-CoV-2 vaccine.”