MedicalXpress Article, Aug 8, 2022
This is an important read. Please refer to the original article for an important diagram.
Popular Rationalists know from my articles and presentations that Dr. Fantini’s results and the evidence of negative efficacy from real-world data means (to me) that ADE has driven SARS-CoV-2 viral infection since the vaccines were first put into humans on a large scale. The mutations that led to vaccine escape predate the vaccine, and that is expected: natural selection can only work on existing variation. The vaccine selection pressure has driven vaccine escape variants to spread throughout the evolving SARS-CoV-2 virus population on the landscape of humans.
Here is the full article that describes another confirming study, this time by Gary Dolton. The conclusion is inescapable: the vaccination program is responsible for the spread of COVID-19.
Please refer to the original article for an important diagram.
AUGUST 8, 2022
SARS-CoV-2 spike mutation that 'escapes' killer T-cells generated by infection and vaccination
U.K. scientists have highlighted a mutation in the spike protein of SARS-CoV-2 that allows the virus to evade important immune cells induced by infection and vaccines.
The P272L Spike mutation first arose during the U.K.'s second wave of COVID-19, which began in September 2020, and has been pinpointed to the part of the spike protein most frequently recognized by killer T-cells. The SARS spike protein is also the basis for current vaccines.
The "escape mutation" has been found in more than 100 viral lineages to date, including those classed as "variants of concern." It has been seen in strains in the U.K. and Europe, and in Australia and the U.S. between September 2020 and March 2022.
When a mutation arises independently multiple times this raises concerns the virus is evolving for a reason such as immune escape.
Now, a new study led by Cardiff University and published in the journal Cell, has shown that the P272L Spike mutation escaped recognition by killer T-cells in a group of health care workers from south Wales infected with SARS-CoV-2 early in the pandemic. The mutation also evaded all T-cells raised against this part of the virus in donors that had been vaccinated.
The researchers say monitoring for "viral escape" is important—and if mutations like P272L start to dominate then future vaccines may need to be altered to include different viral proteins.
Lead author Professor Andrew Sewell, from Cardiff University's School of Medicine and Systems Immunity Research Institute, said: "We studied more than 175 different types of killer T-cells that could see the part of the virus containing the P272L mutation and were surprised to see that this one mutation resulted in escape in all the donors studied.
"Similar escape mutations have been seen in influenza viruses. It has been estimated the virus that caused the 1968 Hong Kong flu pandemic has mutated to escape from recognition by a type of killer T-cell once every three years."
In this study, P272L escaped from more than 175 T-cell receptors—both in the COVID patients and those who had been vaccinated.
Since the Cardiff study was completed, the mutation has been observed in the original omicron variant (BA.1) in England. This variant was outcompeted by other omicron variants (most recently BA.5) that are more transmissible, but the researchers anticipate that the killer T-cell escape mutant may arise and transmit in BA.5 and any subsequent variants.
Professor Tom Connor, an expert in SARS-CoV-2 genomics from Cardiff University's School of Biosciences and Systems Immunity Research Institute, said, "The P272L mutation has arisen in many different SARS-CoV-2 lineages since the start of the pandemic. The independent evolution of the same mutation in multiple viral lineages is an example of homoplasy, which may be suggestive of a mutation that could confer a selective advantage.
"I anticipate that we may see more occurrences of the P272L variant over time, as the virus continues its evolution into a human pathogen. Our work emphasizes how much we still have to learn about SARS-CoV-2, and the importance of monitoring T-cell escape in future."
Dr. Lucy Jones, clinical research lead from Cwm Taf Morgannwg University Health Board who collected the study samples, said, "Our study looked at recognition of the virus spike protein by the most common sort of killer T-cell across the population. If the P272L mutation comes to predominate in time, it might be advantageous to provide vaccine boosts with this new sequence or to extend vaccination to include other viral proteins.
"Current vaccines work well and should still be taken up by people, but our research suggests vaccines may need altering as we learn more about the virus."
Garry Dolton et al, Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope, Cell (2022). DOI: 10.1016/j.cell.2022.07.002
UPDATE: A reader sent me this email:
If the mutation escaped killer T-cells from the unvaccinated as well, i don't understand how the vaccine drove the mutation?
My response: Vaccine antibodies change the virus away from the extant strain.
The virus then interacts with the unvaccinated, most of whom likely have antibodies to a prior strain.
They would like us to believe that the population becomes dependent on updated vaccines.
However, the unvaccinated also have broader and deeper immunity to non-spike proteins.
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"Current vaccines work well and should still be taken up by people, but our research suggests vaccines may need altering as we learn more about the virus."
Yup. Let's keep altering the "vaccine" and jabbing: wash, rinse and repeat.
"Current vaccines work well and should still be taken up by people, but our research suggests vaccines may need altering as we learn more about the virus."
Why is the above statement in the article in support of the current vaccines ??? The vaccines have not only failed, the vaccines are rushed, inadequately tested, dangerous, and driving the pandemic!