Evidence of Autoimmunity Associated with HPV Vaccination

Only data manipulations stand between association. The mechanisms are clear. A new study shows increase autoreactive antibodies. IPAK will analyze HPV viral proteins if you want us to

The Journal of Autoimmunity has published an important major study by Mehlsen et al. (2022), "Autoimmunity in patients reporting long-term complications after exposure to human papilloma virus vaccination".

The authors first mention that the vaccine trials for HPV vaccine did not use inert placebos, but instead used aluminum adjuvant, leading to limitations.

The next reviewed other important studies on the question of the association of autoimmunity following HPV vaccination; you can see that data manipulation is responsible for a big empty set of zero knowledge of the association between HPV vaccination and autoimmunity:

“Two large cohort studies of AEFI with the HPV4 vaccine have been carried out using the hospital-based health care registries of Denmark and Sweden. Both studies only included AEFI with a prespecified ICD-10 code. The first study found a significant association between HPV4 vaccine exposure and Bechet’s syndrome, Raynaud’s disease, and Type-1- diabetes. However, this association was rendered nonsignificant since a clear temporal pattern related to the exposure could not be found [14]. The second study found significantly increased relative risk of Hashimoto’s thyroiditis, coeliac disease, localized lupus erythematosus, pemphigus vulgaris, Addison’s disease, Raynaud’s disease and a mixed group of encephalitis, myelitis, and encephalomyelitis. The statistical significance of these findings disappeared following self-controlled case series analysis, (the) requirement of consistency among the two participating countries, Bonferroni’s correction, and a non-descript clustering analysis [15].

(See? Manipulations…)

“A large French register-based study found a higher risk of Guillain Barr´e syndrome in the HPV-vaccinated population [16]. The epidemiological studies have – in general - several limitations as they only rely on analyzing the occurrence of disease entities that are contained in the databases. Symptoms or syndromes that do not have a specific diagnostic code or in which these codes are not used, will not be included in such analyses. These limitations have been addressed in more recent register-based publications from Denmark by investigating school absence in relation to vaccination [17], or focusing on pain, fatigue, or cardiovascular symptoms [18]. The publication on school absence includes approximately 14,000 girls aged 12–16 years at vaccination and they served as their own controls comparing an unvaccinated period with the period after vaccination. The study did not find any difference between the periods [18]. With the number of girls included and the frequency of side effects reported [19] the study could be expected to have included only 20 to 30 girls with side effect and as such have had a high risk (of) overlooking this signal. The second study [18] did not find any difference in their main analyses of approximately 147,000 girls and could be assumed to have 200 to 300 girls with side effect (sic) but would likely overlook this given that their results have broad confidence limits [18].”

“Two publications based on reported adverse events in the Vaccine Adverse Event Reporting System (VAERS; [20, 21]) found that events with a probable autoimmune background were significantly more frequent after HPV-vaccination compared to other vaccinations. Passive surveillance systems – such as VAERS - are subject to multiple limitations, including underreporting, unconfirmed diagnoses, and lack of denominator data and unbiased comparison groups.”

“During the past years, case series on suspected side effects to the HPV vaccines have described a collection of signs that resemble symptoms in three main diagnostic entities - postural orthostatic tachycardia syndrome (POTS, 22,23,24), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS, 24,25), and complex regional pain syndrome (CRPS, [26]).”

They then go on to describe an amazing clinic set up to study HPV vaccine adverse events:

“In 2015, it was decided to establish centers for patients with possible side effects to HPV-vaccination in each of the five Danish Regions, and the Danish State allocated funding for research into possible biological background for the alleged side-effects. The present study is based on clinical observations and diagnostic testing in a large group of patients referred to the “Center for Patients with Possible Side-effects to HPV Vaccination” in the Capital Region of Denmark.”

Ok, that’s really amazing.

They then drill down into the mechanism they focused on:

“The aim was to analyze a possible connection between biologic(al) and/or pathophysiologic changes and symptoms experienced by girls and young women referred to the center. We specifically aimed to relate symptoms to autoimmunity, as the primary sequence of the HPV major capsid L1s antigen is similar to that of several human autonomic nerve receptors and their related proteins, including adrenergic G-protein coupled receptors (GPCRs) [13, 27], and as previous publications have classified the probable side effects as disease entities known to be associated with neuroendocrine GPCR antibodies (POTS – [28]; CRPS – [29]; ME/CFS – 30) as well as in case stories on patients with probable side effects to HPV-vaccination [31–33].

Interestingly, similar symptoms [34] and neuroendocrine GPCR antibodies are reported in patients suffering from long-term complications after SARS-CoV-2 infection (long-COVID, 35).”

They studied data from patients at the Center (845 patients; 839 females) from 2011 to 2018, who had suspected side effects referred.

A control group was recruited from local educational institutions and were age- and sex-matched, healthy vaccinees.

They studied generic antinuclear antibodies as well as antibodies against G-protein coupled receptors.

Here are the results of the between-group comparison of ANA antibodies. I have reservations, since the controls were not in the same clinic as the cases, and the controls are all vaccinated (w/HPV vaccines). I would think an unvaccinated control group would be more appropriate:

A number of important differences between the cases and controls included VitD , Calcium, HbA1c, creatinine (all lower in cases), and serum albumin, a measure of inflammation (higher in cases).

In 2020, I predicted specific tissues in which we could expect autoimmunity from exposure to SARS-CoV-2 proteins (the first Pathogenic Priming study, now cited by 160 others).

At IPAK, we have completed our analysis of HepB proteins, and we have learned something (potentially, caveat, caveat) about the etiology of HepB viral pathogenesis as well as vaccine-induced autoimmunity. The paper for that study is under review.

We’ve also finished our pathogenic priming analysis for measles, mumps and rubella. That study is being written up now.

Next, we will focus on pathogenic priming analysis of HPV viral protein for more specific findings of autoimmune triggers and targets from HPV vaccination.

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Citations

Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. J Transl Autoimmun. 2020 Apr 9;3:100051. doi: 10.1016/j.jtauto.2020.100051. PMID: 32292901; PMCID: PMC7142689.

Mehlsen J, Brinth L, Pors K, Varming K, Wallukat G, Olsen RKJ. Autoimmunity in patients reporting long-term complications after exposure to human papilloma virus vaccination. J Autoimmun. 2022 Nov 7;133:102921. doi: 10.1016/j.jaut.2022.102921. Epub ahead of print. PMID: 36356549.