Autism Following Vaccination and Eczema Following Vaccination Are Linked Causally via IL-6. Are Luteolin and Quercetin Therefore Possible Solutions Post-Vaccination?
Eczema used to be used by doctors as a clear indication that bad things might happen if an infant was vaccinated. A new study linking Eczema and severe ASD is worth a good look.
Years ago, pediatricians knew that vaccinating some children could be risky. They also knew that vaccinating some children under certain conditions was risky.
That knowledge has all but been destroyed by the Denialista, but somehow scientists keep rediscovering denied causal links. Two conditions of “unknown cause” seem to share a common cause with “Factor X”. But we’ll get to that…
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Here's a piece by Dr. Auwaerter on Eczema Vaccinatum, first published in 2014, in which he reports that "Eczema is the most common contraindication to the (smallpox) vaccine, and EV was the most common cause of vaccine mortality in the 1960s."
Wow. “Vaccine mortality”. How long before Johns Hopkins changes that webpage?
Anyway, consider the piece by Valman, published in the British Medical Journal in 1980 “The First Year of Life: CONTRAINDICATIONS TO IMMUNISATION”, a whole suite of contraindications is noted. What information di physicians know then that is being ignored now by ACIP, the AMA, and Medical Boards?
“Contraindications to whooping cough vaccine are: fits or abnormal cerebral signs in the neonatal period, neurological abnormalities, developmental delay, and a family history of epilepsy or other diseases of the central nervous system. A general or local reaction to a preceding dose suggests that the vaccine should be avoided.
Acute infection is a contraindication to routine tetanus immunization, though not in the presence of a tetanus-prone wound. When a child has suffered from a severe local reaction to a previous dose of adsorbed vaccine it may be preferable to administer 0.1 ml of tetanus vaccine in simple solution intradermally.
Apart from acute infection there are no contraindications to immunisation with diphtheria vaccine.
Live vaccines include BCG, poliomyelitis, measles, rubella, and smallpox vaccines, and they have many contraindications in common: they should not be given to infants with any immunological abnormality, including a low plasma IgG concentration; those with malignant diseases; or those receiving corticosteroids or immunosuppressive treatment.
Measles and rubella vaccines should not be given to infants aged under 1 year. They should also not be given within the incubation period to those who have been exposed to an infectious disease.
Rubella vaccine should not be given to children with known thrombocytopenia or a personal or parental history of fits. It should also not be given to children who are hypersensitive to neomycin.
Infants with the following conditions should not be given measles vaccine unless human normal immunoglobulin (1-3 mg/kg body weight) with a specific content of measles antibody is given simultaneously at a different site: (a) a history of convulsions; (b) parental history of epilepsy (non-traumatic); (c) chronic disease of the heart or lungs; (d) serious failure to thrive. In the first three groups immunisation could be delayed until after the second birthday.
Smallpox vaccine is not now used routinely in the United Kingdom. It should not be given to infants with eczema or a history of it, and after vaccination infants must be kept from contact with anyone with eczema for 21 days.
BCG should also not be given to infants with chronic skin conditions such as eczema.
Oral poliomyelitis vaccine is contraindicated in children hypersensitive to penicillin, streptomycin, or neomycin.
Dr H B VALMAN, MD, FRCP, is consultant paediatrician,
Northwick Park Hospital and Clinical Research Centre
Where are those contraindications now?
It turns out that these contraindications were thrown out by a scheme that involved discrediting Dr. Andrew Wakefield specifically to create a cultural taboo against criticizing vaccines. Those cost to society has been immense. Of course, studies are now, nevertheless, re-discovering links between common outcomes of vaccination.
A growing number of studies have found an increase in the risk of autism after the MMR – if Paracematol (Acetaminophen, e.g., Tylenol™) is administered to ease the fever. These include:
Schultz ST, Klonoff‐Cohen HS, Wingard DL, Akshoomoff NA, Macera CA, Ji M. 2008 Acetaminophen (paracetamol) use, measles‐mumps‐rubella vaccination, and autistic disorder: the results of a parent survey. Autism. 12(3):293‐307. doi: 10.1177/1362361307089518.
Bauer AZ, Kriebel D. Prenatal and perinatal analgesic exposure and autism: an ecological link. Environ Health. 12:41. doi: 10.1186/1476‐069X‐12‐41.
Claudia B. Avella‐Garcia, Jordi Julvez, Joan Fortuny, Cristina Rebordosa, Raquel García‐Esteban, Isolina Riaño Galán, Adonina Tardónf, Clara L. 2016. Rodríguez‐Bernal, Carmen Iñiguez, Ainara Andiarena, Loreto Santa‐Marina, Jordi Sunyer. Acetaminophen Use in Pregnancy and Neurodevelopment: Attention Function and Autism Spectrum Symptoms. International Journal of Epidemiology DOI:10.1093/ije/dyv
In 2010, Shoffner et al., (2010) found that 71% of kids with regressive autism had an episode of fever > 101°F In 33% of these cases, the fever occurred right after vaccination – and none showed regression unless fever had occurred:
Shoffner J, Hyams L, Langley GN, Cossette S, Mylacraine L, Dale J, Ollis L, Kuoch S, Bennett K, Aliberti, A, Hyland K. 2010. Fever plus mitochondrial disease could be risk factors for autistic regression. J Child Neurol. 25(4):429‐34. doi: 10.1177/0883073809342128.
In July 2017, I sent these studies, along with copies of my book, to over 100 Deans of Schools of Medicine. Their response was to mildly nudge, via Paul Offit, that perhaps pediatricians were being too aggressive against vaccine-induced fevers.
But is the ASD risk the acetaminophen, the fever, or both? Let’s see:
Vaccination —> Fever —> Autism
Vaccination —> Fever —> Acetaminophen —> Autism
Either way, vaccination caused the fever, which caused the acetaminophen exposure, so vaccination would be the root cause. (Many parents used to be told to prepare their children for vaccination by pre-dosing them with Acetaminophen!)
A new study, published in Translational Psychiatry, found that children with ASD who also have an atopic condition such as eczema are more likely to have more severe ASD symptoms.
“Eczema is a condition that causes the skin to become red, itchy, and inflamed. It is also known as atopic dermatitis. Eczema is a chronic condition that can be difficult to manage. The exact cause of atopic eczema is unknown, but it is thought to be caused by a combination of genetic and environmental factors.
‘There is an interesting overlap between eczema and neurodevelopmental conditions that warrants further investigation,’ said study author Adam Guastella, the Michael Crouch Chair in Child and Youth Mental Health at the University of Sydney.
‘We have long known that children with neurodevelopmental conditions often have a higher rate of eczema and allergies. There has been limited research to show whether having eczema and atopic diseases (sic, jointly) is also linked to more severe symptoms of neurodevelopmental conditions. Understanding this link better may provide leads into detection and intervention opportunities that can support both conditions.’
Take a look at vaccines. Wait, that’s right. You can’t. You’re not allowed.
‘We have recently developed a model that highlights many of the co-occurring molecular features of autism and eczema and the evolutionary significance of the skin-brain connection. There is growing research about how the skin and brain co-develop and are subject to similar genetic and environmental factors that may drive development of both. This idea has been summarised in a paper published in Molecular Psychiatry. Interestingly, we argue that the skin may provide useful insights that can also tell us about brain development.’
Let me guess; IL-6, right? (Google “What is IL-6?”)
Now how did I know that?
“For their study, the researchers examined data from 140 children with ASD, who were about 6 years old on average. The children were recruited from the Clinic for Autism and Neurodevelopment (CAN) Research at the University of Sydney and the Child Development Unit at Westmead’s Children’s Hospital. The child’s parent or caregiver completed an assessment of atopic diseases, including asthma, allergies, eczema and hay fever. Atopic conditions were found in 47 children.
Guastella and his colleagues found that children presenting with an atopic comorbidity tended to have more severe autism symptoms, as measured via the Autism Diagnostic Observation Schedule. The findings provide evidence “that there is an interesting relationship with skin conditions and autism symptoms that requires further evaluation,” he told PsyPost. “It seems that those children with eczema in particular also have more severe symptoms of neurodevelopmental delay. We need to understand why. It may lead to opportunities for earlier detection and supports to improve outcomes for both developmental processes.”
Others are finding a similar link; See "Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children"
‘Having an eczema (or atopic disease broadly) more than doubled a child’s chance of scoring on the severe end of autism symptoms and social difficulty symptoms, as rated by clinicians,’ Guastella noted. ‘That was a big jump that warrants further investigation. While there has long been acknowledgement (sic) that kids with neurodevelopmental condition (sic) have a higher rate of skin conditions, this is one of the first to suggest a link with the severity of autism symptoms.’
The main limitation of the study is the cross-sectional nature of the data. The link between atopic conditions and autism severity could be “incidental,” Guastella said. “Research examining causal pathways are required.’”
Yes, but here’s the rub: Eczema didn’t double the children’s chance of scoring on the severe end of autism symptoms and social difficulty symptoms. What did?
X——> ASD severity
These authors pointed to IL-6.
X—> IL-6 —> Eczema
X—> IL-6 —> ASD severity
What could factor X be???
Well, it turns out that four hours after vaccination, IL-6 increases. Moreover, there is variation in the human population - contributed to in part by genetics - as to who has a higher and more sustained IL-6 increase due to vaccination.
Elevated IL-6 and IL-17A have been detected in the plasma and serum of children with ASD, and it seems these cytokines may cross the blood brain barrier and provoke neuroinflammation in circuitry regulating developmental outcomes (e.g., cause chronic microglia activation, just a Dr. Blaylock and others told us years ago).
Look, from 2004:
“Astrocytes, microglia, and neurons express the cytokine interleukin-6 (IL-6), which in the brain has been suggested to reduce food intake, inhibit memory and learning, cause neurodegeneration, and exacerbate sickness behavior induced by other cytokines.”
New research has reported in detail a “skin-brain connection”:
“Early life development and its divergence is influenced by multiple genetic, neurological, and environmental factors. Atypical neurodevelopment, such as that observed in autism spectrum disorder, likely begins in early gestation during a period of entwined growth between the brain and epithelial barriers of the skin, gastrointestinal tract, and airway. This review coalesces epidemiological and neuroinflammatory evidence linking cutaneous atopic disease with both reduced skin barrier integrity and determinants of neurodivergence. We consider the shared developmental origin of epidermal and neural tissue with related genetic and environmental risk factors to evaluate potential pre- and postnatal modifiers of the skin-brain connection. Initial postnatal skin barrier integrity may provide a useful marker for both cortical integrity and meaningful subgroups of children showing early neurodevelopmental delays. It may also modify known risk factors to neurodevelopment, such as pathogen caused immune system activation. These novel insights of a skin-brain-neurodevelopment connection may advance detection and intervention opportunities.”
What’s happening with vaccination in pregnancy, when the brain undergoes such profound development?
For example, maternal levels of pro-inflammatory IL-6 and C-reactive protein levels in the third trimester are associated with offspring cognitive functioning and behavior
In my mind, having read >2,000 studies on autism for my book, there is little mystery in the causal network between Eczema and ASD. A skin graft study in mice moving skin with eczema caused by vaccination from a vaccinated mouse to a non-vaccinated mouse compared to a skin graft-only control might help rule out whether the skin reaction itself is in the causal pathway to autism following vaccination or leads to inflammation in the brain.
But either way, as a fundamental exposure, vaccination is a root cause of both.
Vaccination —> IL6 —> Eczema
Vaccination —> IL6 —> ASD
Vaccination —> IL6 —> Eczema —> ASD
Either way, vaccination is a root cause.
When you dig deeper, there are more complicated factors involved.
See, for example, The IPAK Model of ASD Causality (aka "The IPAK Model").
Vaccines have multiple effects on the body, and the effects vary with genetics and prior exposure. Contrary to what the dumpster fire of executive branch administered “justice”, the NVICP, would have us believe, the evidence is overwhelming that vaccines are clearly a root cause. And the genetic study cited gives me hope that we might easily predict who is at risk of these serious adverse reactions.
But the denialista will merely attack, deny, and keep science stalled - at immense cost to families and individuals.
You can also check out VaccinePapers.org’s reports on IL-6 and autism.
By the way, Fluoxetine Ameliorates Atopic Dermatitis-Like Skin Lesions in BALB/c Mice through Reducing Psychological Stress and Inflammatory Response.
The mechanism of action?
“Presynaptic serotonin (5HT1A) receptors are in the dorsal raphe nucleus and project to the prefrontal cortex. Fluoxetine exerts its effects by blocking the reuptake of serotonin into presynaptic serotonin neurons by blocking the reuptake transporter protein located in the presynaptic terminal”.
Oh, look! Serotonin Increases Interleukin-6 Synthesis in Human Vascular Smooth Muscle Cells
But seizures from vaccines, the doctors have said, are “normal”.
Screaming after vaccines, they say, is “normal”.
We need to stop poisoning our children and our pregnant mothers. And medicine we need to grow the f*** up and start doing studies on how to safely ameliorate - in real time - the severe reactions to vaccines and save these kids’ brains from harm.
In my readings for my book on autism in 2015, I found several foods that can calm activated microglial.
Chamomile tea contains luteolin. So do carrots, peppers, thyme, rosemary, celery, olive oil, oregano, and peppermint - all significant dietary sources of luteolin.
See: Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease mode
Here’s a nice 2018 paper on the Rationale for Dietary Antioxidant Treatment of ADHD
And guess what? Here’s a review of its potential for cancer prevention:
Luteolin, a flavonoid with potentials for cancer prevention and therapy .
So, where’s the study of luteolin supplements following vaccination to reduce unwanted side effects?
Well, it helps BCG vaccination efficacy:
Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice
Quercetin is structurally similar to luteolin. Here’s a letter to the editor pointing to evidence that Quercetin may ameliorate the toxic effects of COVID-19 vaccines while also reducing the chance of infection:
Quercetin Supplementation and COVID-19
Quercetin is a second-line treatment for long-haul COVID-19 in the FLCCC’s protocol.
Here are studies on luteolin worth reviewing.
Should we demand studies of post-vaccination therapies, say, a week-before and week-after treatment with luteolin or Quercetin following all vaccines to study the effects on reducing the negative impacts of vaccines overall, and recommend that kids keep taking organic these as organic flavonoid supplements if they appear to help?
Should we screen kids and families with genetics to determine if they are at risk?
And/Or should we remove the offending metals and proteins from vaccines that cause these problems in the first place?
What are your thoughts?
Here’s a video synopsis of Dr. Chris Shaw’s upcoming class next semester @ IPAK-EDU.org: “Controversies in Neurodevelopmental Disorders and Diseases”.
Bennermo M, Held C, Stemme S et al. Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases? Clin Chem 2004; 50: 2136–2140.
Jameson, C., Boulton, K.A., Silove, N. et al. Ectodermal origins of the skin-brain axis: a novel model for the developing brain, inflammation, and neurodevelopmental conditions. Mol Psychiatry (2022). https://doi.org/10.1038/s41380-022-01829-8
Spann MN, Monk C, Scheinost D, Peterson BS. Maternal immune activation during the third trimester is associated with neonatal functional connectivity of the salience network and fetal to toddler behavior. J Neurosci. (2018) 38:2877. doi: 10.1523/JNEUROSCI.2272-17.2018
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Side note on eczema...Paul Saladino, MD talks a lot about how having eczema led him down the path towards a carnivore diet in his book. Essentially, plants were causing it. Specifically, phytoalexins (plant defense chemicals) were the problem in his autoimmune condition...https://youtu.be/KXijeatS_Ik Fascinating rabbit holes to go down in regards to lectins, oxalates, etc...
I stopped getting the flu vaccine around 2004 bs it was a coin flip whether I contracted the flu or not. Since then no flu except 2018 which was a bad flu season and I made a bad decision to eat at a diner with a couching worker.