There is One Thing You Can Do About the Discovery of Immune Tolerance of SARS-Cov-2 Due to Repeat Vaccination
It would be a luxury to feel angry or scared. I feel sadness and the urge to educate.
A ton of people have emailed me about this article, asking me my opinion and interpretation.
Study: Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination
When I teach immunology, I stress that the most important aspect of the biology of our immune system is the aspect of tolerance: that, more importantly than learning to detect new antigens from bacteria, parasites and viruses, our immune systems also learn - and re-learn - self vs. non-self.
If our immune systems were to adapt to mis-learn that a viral protein was self, the tolerance of virus would have obvious consequences. That person would be at risk of serious disease from rampant infection.
Here’s the Abstract from the study from Germany:
“High levels of neutralizing SARS-CoV-2-antibodies are an important component of vaccine-induced immunity. Shortly after the initial two mRNA vaccine doses, the IgG response mainly consists of the pro-inflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of non-inflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections. IgG4 antibodies among all spike-specific IgG antibodies rose on average from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination. This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors. Single-cell sequencing and flow cytometry revealed substantial frequencies of IgG4-switched B cells within the spike-binding memory B-cell population (median 14.4%; interquartile range (IQR) 6.7-18.1%) compared to the overall memory B-cell repertoire (median 1.3%; IQR 0.9-2.2%) after three immunizations. Importantly, this class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition. Since Fc-mediated effector functions are critical for antiviral immunity, these findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2.”
It does not get much worse than this. This is not theoretical, and seems to involve SARS-CoV-2 spike protein because the switching occurs after mRNA vaccination and infection as well. A previous study had reported that the induction of non-inflammatory IgG4 antibodies and their presence in the serum of COVID-19 patients was previously associated with bad clinical outcomes. There is concern - but no definitive evidence - that COVID-19 infection might also pull IgG4 diseases out of remission (see this case report).
To see class switching in the twice- and thrice-vaccinated (I count the initial vaccine exposure as “vaccinated”) is bad news for the obvious reason that we would hope to and expect to see IgG1 and IgG3 responses. Instead, we see the induction of acute phase reactants (APRs) in the presence of IgG4 - an odd mix spun as “important” as the APRs are claimed to be proof that the vaccine is “working”. Vaccines that induce tolerance to the pathogen cannot be said to be “working” - vaccines are supposed to “prevent transmission”, not render one helpless to eternal repeated infection/vaccination cycles.
But there’s another aspect of class switching that I have not seen explored sufficiently. If our own cells start producing spike following genomic uptake of the mRNA, we would not expect much change in our overall biology because we should see those cells die due to an immune reaction. If immune system does not detect infected or transfected cells, the biology of those cells will remain altered, and general, hard-to-diagnose, non-descript “-algias” and malaise will manifest - a boon to allopathic medicine that superficially treats disease symptoms - you know the routine.
The Entire Warning Re: Pathogenic Priming Has Been Missed By Allopathic Medicine and by Many Who Discuss the Perils of COVID-19 Vaccines
The lesson from pathogenic priming is simple: more exposures means more immune disasters. In thrombocytopenia and other forms of immunopenia, for example, the scientific literature cites the IPAK April 2020 finding that 1/3 of the proteins to which SARS-CoV-2 shows risk of autoimmunity via pathogenic priming involve the immune system.
My predictions from April 2020 have sadly been born out by the scientific literature.
From Bhattacharjee and Banerjee (2020):
“Cytotoxic CD8+ T cells can directly cause platelet lysis, induce the apoptosis of platelets, and inhibit platelet production by megakaryocyte maturation [57]. Low or dysfunctional regulatory CD4+ T cells can also be seen in patients with ITP, pointing towards their possible role [57]. COVID-19 patients with immune dysregulation can have lower levels of regulatory T cells, which are more decreased in severe cases [59]. This can explain the greater occurrence of ITP in moderate-to-severe COVID-19 cases of this review. Remarkably, greater than one-third of the immunogenic proteins in SARS-CoV-2 have been found to have homology to proteins that are essential to human adaptive immune system [60 (Lyons-Weiler, 2020)]. Autoimmunity against these proteins and their interactors may impact several functions of adaptive immune system, including MHC class I and class II antigen presentation, cross-presentation of exogenous antigens, and PD-1 signaling [60]. All these may have a role to play in the development of immune cytopenias.”
And from Quinn and Murakhovska (2020):
…greater than one-third of the immunogenic proteins in SARS-CoV-2 have been shown to have homology to proteins essential in the human adaptive immune system, providing support to the role of pathogenic priming in disease severity by induction of autoimmunity [32 (Lyons-Weiler, 2020)]. Induction of the autoimmune response against proteins in the adaptive immune system can impair major histocompatibility complex (MHC) class I and class II antigen presentation, cross-presentation of exogenous antigens, and programmed cell death protein 1 (PD-1) signaling [32], further contributing to immune dysregulation.
Other stackers have written about the class-shifted study as well (see below). It’s all terribly depressing. Like I said, it would be a luxury to be angry or afraid. It’s important that we understand the pathways to health for these people, and for ourselves to limit the chronic illness these vaccines and this virus are imposing on our species.
In 2020 alone, 14 studies cite the original Pathogenic Priming results, I’m sad to say, with evidence of myriad autoreactogenicity (see them here).
Far from beating my chest, I am deeply saddened that the way to avoid pathogenic priming induced morbidity and mortality is avoid repeated exposures to SARS-CoV-2 proteins. Obviously, with eternal boosters, the cycle of
vaccine → infect → vaccinate → infect —>…
will be eternal for those stuck in that loop, with I would expect 4-6 infections per year for some - their immune systems being confused, Th2-skewed, class-shifted, ground to dust.
Other stackers have written about the class-shifted study as well (see below). It’s all terribly depressing. Like I said, it would be a luxury to be angry or afraid. It’s important that we understand the pathways to health for these people, and for ourselves to limit the chronic illness these vaccines and this virus are imposing on our species.
I’ve created an online University to teach people what we learn, as we learn it. Dr. Christina Parks is offering an amazing course via IPAK-EDU in which front-line physicians relay the therapies and interventions that on the board for further study to reduce these types of medical events.
The course is being considered right now for CMEs for physicians. Tell your doctors about this - naturopaths, osteopaths, chiros and allopaths. The solutions are not complete, but the considerations are deep. Please forward this email to physicians and people who want to learn what their doctors might benefit from this training.
Click on the image or link to register for the course. A monthly payment option is available.
There’s no time to sound more warning bells. It’s time to create the new future, teach the new doctors, and you can be a part of that. I urge you to join Dr. Parks and Maija Hahn in this course.
Other than this, all I can do at this point is share my remorse and sadness that more people were not warned in time.
Citations
Bhattacharjee S, Banerjee M. Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review. SN Compr Clin Med. 2020;2(11):2048-2058. doi: 10.1007/s42399-020-00521-8. Epub 2020 Sep 19. PMID: 32984764; PMCID: PMC7501509.
Quinn R and I Murakhovskaya. 2021. SARS-CoV-2 and Autoimmune Cytopenia. Hemato 2021 2(3) 463-476
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I share your sorrow, James, and predicted the same thing despite having no medical background, thanks to my familiarity with dedicated health care servants such as yourself. Your compassion has been obvious to me since I first discovered your Stack. Thank you for all you do.
A very informative article for those of us who are not experts. I had no idea how our immune system works prior to the pandemic. Spike tolerance, like insulin resistance in diabetics sounds like a disaster.