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Joe's avatar

Amazing to think (and kind of obvious) that something as fundamental as our sleep/wake cycles may make all the difference to NLRP3. Dark during the night, light during the day. Melatonin and vitamin D both have a strong modulatory effect on NLRP3. Turn off the TV...get some sleep...get some sun.

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Brian Mowrey's avatar

I had to go read the study to clarify if the findings suggest that post-infection NLRP3 inflammatory pathways were chronically active - "unleashed" as you put it. It seems just that recovered CD14+ cells are primed to form inflammasomes upon reencounter with spike, whereas naive donor CD14+ cells do not react to spike. So, only a concern for "long-haulers" and for the vaccinated as you said.

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