Repeated Exposures to SARS-CoV-2 Spike Proteins Associated with Increased Risk of Adverse Events

#Pathogenicpriming #ADE

CNN and MEDPAGE Today published about articles about a study that allegedly shows that people who had adverse events had a stronger antibody response. Their interpretation? Doctors should tell their patients that their adverse reaction is evidence that the vaccine is “working”.

From CNN:

“People who reported experiencing side effects to the Pfizer/BioNTech and Moderna Covid-19 vaccines such as fever, chills or muscle pain tended to have a greater antibody response following vaccination, according to new research.

Having such symptoms after vaccination is associated with greater antibody responses compared with having only pain or rash at the injection site or no symptoms at all, suggests the paper published Friday in the journal JAMA Network Open.

‘In conclusion, these findings support reframing postvaccination symptoms as signals of vaccine effectiveness and reinforce guidelines for vaccine boosters in older adults,’ the researchers – from Columbia University in New York, University of Vermont and Boston University – wrote in their paper.”

Note CNN left of “older” before “people”.

This study, and the press’s generalization of the finding to “people” prompted me to have this done. (Feel free to download this image asset and use it wherever you like (no copyright), but please link back to the source.)

Then there’s this study, that shows that having COVID-19 prior to vaccination is associated with increased risk of adverse events (#PathogenicPriming), leading the authors to conclude that perhaps vaccinating those who have natural immunity might be a bad idea:

“This study of healthcare workers demonstrated that prior COVID-19, but not Long-COVID, was associated with increased risk of AEs following BNT162b2/Pfizer vaccination, although there was no relationship with duration since COVID-19 illness.”

“Women and younger individuals were also more likely to report AEs. Our study adds to other reports supporting the wider understanding of AEs following COVID-19 vaccination [1], [2], [3], [4]. Importantly, given hesitancy surrounding recently developed COVID-19 vaccines [6], our findings may help inform those with previous COVID-19 of increased susceptibility to certain AEs. Our study also adds weight to the question of whether a second dose of mRNA vaccine is necessary in those with previous COVID-19, assuming effective immunity is established after the first dose [1,2,8,9]. This is relevant, given that Tre-Hardy's and other studies have reported worse AEs following second doses of vaccine…”

Pubmed Central Link

Raw RK, Kelly CA, Rees J, Wroe C, Chadwick DR. Previous COVID-19 infection, but not Long-COVID, is associated with increased adverse events following BNT162b2/Pfizer vaccination. J Infect. 2021 Sep;83(3):381-412. doi: 10.1016/j.jinf.2021.05.035. Epub 2021 May 29. PMID: 34062184; PMCID: PMC8164507.

H/T Paul Alexander for that latter study.