Ever Wonder How Data from Vaccine Safety Studies Are Analyzed?

Summer course: The Math of Vaccine Science

This course is co-taught by Dr. James Lyons-Weiler and Dr. Cathy Stein (Epidemiologist).

The Math of Vaccine Science (IPAK-EDU)

SUMMER (July 2023)

Syllabus - Subject to Change

In this class, students will learn the fundamentals of the analysis of data from retrospective studies - the most common studies used to assess long-term vaccine safety. Stdents will be introduced to the mathematical operations conducted in the study of vaccine safety and efficacy. They will learn from real-world examples.

Instructors: C. Stein, J. Lyons-Weiler

1. Simple operations in Excel

2. Plotting results in Excel

3. OR - Odds Ratios

4. RR - Relative Risk

5. Absolute Risk vs Absolute Risk

6. Incidence Rate Ratio (IRR)

7. Assessing "significance" - p-values - Association Tests

8. Confidence Intervals - Calculating CIs in Excel (Data CIs vs. Distributional CIs)

9. Outcomes - 1 - Neutralizing Ab response, Ab response, B-cell and T-cell response

10. Outcomes 2 - Hospitalization and Deaths

11. Vaccine Efficacy

12. Statistical Power Curves

13. Definition of Cases

Symptomatic Cases - Indeterminate or mixed diagnosis

Medical Cases - Determine (definitive diagnoses)

Molecular Cases - RT-PCR/Antigen + vs -

Calculating Diagnostic Accuracy: TP, TN, FP, FN, PPV, NPV, Accuracy, ROC Curves

15. Confounding and what to do about it

16. Stratified Analysis: Interpreting subgroup analyses

17. Student Data Challenge 1

We will show examples in epidemiology where each was used appropriately, and then examples in vaccinology where they have been misapplied or misinterpreted.

Analytics 300 The Math of Vaccine Science (ipak-edu.org)

SUMMER 2022 AT-A-GLANCE

Tues 11AM The Math of Vaccine Science

Wed 11AM ET Medical Ethics and Informed Consent

Wed 1PM Microbiome Master Class

Thurs 11AM Bioinformatics

Thurs 3PM Constitutional Law Bootcamp