What Causes the Top 100 Chronic Illnesses in America: Part 1

Here is a working list of the top 100 Chronic Illnesses in the US - based on breadth and on prevalence (superset). This is the first of 3 articles.

Secretary Kennedy’s MAHA mandate is to reduce chronic illness in America. Let’s get into chronic illness.

This is the first of in a series articles to help the public realize what chronic illnesses are plaguing America and their likely root causes, including iatrogenic causes (such as drug or vaccine side effects).

We’ll start by putting the superset list right here:

CARDIOVASCULAR / METABOLIC (20)

1. I10 — Essential (primary) hypertension

2. I11.0 — Hypertensive heart disease with heart failure

3. I11.9 — Hypertensive heart disease without heart failure

4. I21.3 — ST elevation (STEMI) of unspecified site

5. I25.10 — Atherosclerotic heart disease of native coronary artery without angina

6. I50.9 — Heart failure, unspecified

7. I48.91 — Unspecified atrial fibrillation

8. I63.9 — Cerebral infarction, unspecified

9. I65.29 — Occlusion and stenosis of unspecified carotid artery

10. I20.9 — Angina pectoris, unspecified

11. E78.5 — Hyperlipidemia, unspecified

12. E78.0 — Pure hypercholesterolemia, unspecified

13. E78.1 — Pure hyperglyceridemia

14. E66.9 — Obesity, unspecified

15. E66.01 — Morbid (severe) obesity due to excess calories

16. E66.1 — Drug‑induced obesity

17. R73.9 — Elevated glucose, unspecified (prediabetes)

18. R63.5 — Abnormal weight gain

19. R63.6 — Abnormal weight loss

20. I87.2 — Venous insufficiency (chronic)

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DIABETES / ENDOCRINE (8)

21. E11.9 — Type 2 diabetes mellitus without complications

22. E11.22 — Type 2 diabetes mellitus with diabetic chronic kidney disease

23. E11.65 — Type 2 diabetes mellitus with hyperglycemia

24. E10.9 — Type 1 diabetes mellitus without complications

25. E16.1 — Other hypoglycemia

26. E03.9 — Hypothyroidism, unspecified

27. E05.90 — Thyrotoxicosis without thyrotoxic crisis

28. E89.1 — Postprocedural hypoinsulinemia

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RESPIRATORY (10)

29. J44.9 — COPD, unspecified

30. J45.909 — Asthma, unspecified, uncomplicated

31. J45.22 — Mild intermittent asthma with (acute) exacerbation

32. J96.10 — Chronic respiratory failure

33. J98.4 — Other disorders of lung

34. E84.9 — Cystic fibrosis, unspecified (chronic component)

35. R06.02 — Shortness of breath

36. J47.9 — Bronchiectasis, uncomplicated

37. J42 — Unspecified chronic bronchitis

38. J60 — Coalworker’s pneumoconiosis

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MUSCULOSKELETAL & PAIN (10)

39. M17.9 — Osteoarthritis of knee, unspecified

40. M19.90 — Osteoarthritis, unspecified site

41. M54.5 — Low back pain

42. M25.50 — Pain in unspecified joint

43. M48.02 — Spinal stenosis, unspecified region

44. M13.9 — Polyarthritis, unspecified

45. M79.1 — Myalgia

46. M79.7 — Fibromyalgia

47. M16.9 — Osteoarthritis of hip, unspecified

48. M47.812 — Spondylosis without myelopathy or radiculopathy, lumbar region

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MENTAL HEALTH / NEUROCOGNITIVE (12)

49. F33.1 — Major depressive disorder, recurrent moderate

50. F41.9 — Anxiety disorder, unspecified

51. F32.A — Depression, unspecified

52. F43.21 — Adjustment disorder with depressed mood

53. F45.41 — Pain disorder exclusively related to psychological factors

54. F02.80 — Dementia in other diseases classified elsewhere without behavioral disturbance

55. F03.90 — Unspecified dementia without behavioral disturbance

56. G31.84 — Mild cognitive impairment

57. R41.83 — Mild cognitive impairment, unspecified

58. F11.20 — Opioid dependence, uncomplicated

59. F63.9 — Impulse control disorder, unspecified

60. Z91.19 — Patient’s noncompliance with medical treatment

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CHRONIC KIDNEY / UROLOGIC (6)

61. N18.9 — Chronic kidney disease, unspecified

62. N18.30 — CKD, stage 3 unspecified

63. N18.4 — CKD, stage 4

64. N18.6 — End‑stage renal disease

65. N19 — Unspecified kidney failure

66. R35.0 — Frequency of micturition

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GASTROINTESTINAL / HEPATIC (8)

67. K21.9 — Gastroesophageal reflux disease without esophagitis

68. K29.70 — Gastritis, unspecified, without bleeding

69. K76.9 — Liver disease, unspecified

70. K74.60 — Unspecified cirrhosis of liver

71. K58.9 — Irritable bowel syndrome without diarrhea

72. K59.00 — Constipation, unspecified

73. R10.9 — Abdominal pain, unspecified

74. R11.10 — Nausea with vomiting, unspecified

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NEUROLOGIC / PAIN (6)

75. G43.909 — Migraine, unspecified

76. G44.1 — Vascular headache, not elsewhere classified

77. G62.9 — Polyneuropathy, unspecified

78. G89.29 — Other chronic pain

79. R51 — Headache

80. R52 — Pain, unspecified

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IMMUNOLOGIC / AUTOIMMUNE / OTHER (10)

81. M32.9 — Systemic lupus erythematosus, unspecified

82. M05.79 — Rheumatoid arthritis with rheumatoid factor of multiple sites

83. M06.9 — Rheumatoid arthritis, unspecified

84. L40.9 — Psoriasis, unspecified

85. D89.9 — Disorder involving immune mechanism, unspecified

86. L93.0 — Discoid lupus erythematosus

87. L20.9 — Atopic dermatitis, unspecified

88. R53.1 — Weakness

89. R53.2 — Functional quadriplegia

90. Z79.899 — Other long term (current) drug therapy

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COMMON CANCERS (8)

91. C50.9 — Malignant neoplasm of breast, unspecified

92. C61 — Malignant neoplasm of prostate

93. C34.90 — Malignant neoplasm of unspecified part of unspecified bronchus or lung

94. C18.9 — Malignant neoplasm of colon, unspecified

95. C43.39 — Malignant melanoma of skin, unspecified

96. C25.9 — Malignant neoplasm of pancreas, unspecified

97. C67.9 — Malignant neoplasm of bladder, unspecified

98. C16.9 — Malignant neoplasm of stomach, unspecified

99. C22.0 — Liver cell carcinoma

100. C50.911 — Malignant neoplasm of right female breast

In the next article, we’ll look at known relationships between pharmaceutical drugs as known causes, effectors, mediators, and exacerbators of these conditions.